•) Inflammation of Aorta & its main branches.
Normally
When systolic = Aorta stretch.
And during diastolic Aorta relax.
But due to inflammation this was disturb.
Manifestation of major vessels -> loss of pulses.
If Inflammation of large blood vessels cause Takayasus disease.
•) If inflammation of medium muscular artery-
Lead to formation of thrombus leading to infarct.
•) If small vessels vasculitis leison -
Because of lumen is small it is ruptured and Antigen & Antibody deposite inflammatory cell and cause Microhemorragec PURPURA.
Causes of purpura is ->
1) Severe fragile capillary wall ( collagen doesn't properly form ) due to severe Vitamin C deficiency and this is seen in Scurvey.
2) Thrombocytopenia.
3) Microvasculature vasculitis (pulpable purpura) .
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